GLOBAL ORCHESTRA
- Dienstag, 17 November 2015 05:21
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Deficiency in any required amino acid or cofactor can impair the synthesis of dopamine, norepinephrine, and epinephrine.
Norepinephrine is converted into epinephrine by the enzyme phenylethanolamine N-methyltransferase with S-adenosyl-L-methionine as the cofactor.
L-DOPA is converted into dopamine by the enzyme fragrant L-amino acid decarboxylase (also
acknowledged as DOPA decarboxylase), with pyridoxal phosphate as the cofactor.
Dopamine is transformed into norepinephrine by the enzyme dopamine β-hydroxylase, with O2 and L-ascorbic
acid as cofactors. Because of the greater stability and drinking water-solubility of the protonated form,
dopamine is provided for chemical or pharmaceutical use as dopamine
hydrochloride-that is, the hydrochloride salt that is developed when dopamine is put together with hydrochloric acid.
Outside the central nervous process, dopamine features principally as a neighborhood paracrine messenger.
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